Phloretin is a naturally occurring flavonoid found in apples and in the bark of apple trees. Research has shown that it holds powerful antioxidant, anti-carcinogenic, and anti-inflammatory properties.
When applied topically, phloretin exerts a multitude of skin benefits such as: free radical damage protection and DNA repair, inhibition of lipid peroxidation, inhibition of cancer cells like B16 melanoma, anti-glycation properties (delays the transportation of sugar into skin cells, preventing the hardening of collagen), inhibition of the enzyme MMP-1, which prevents the break down of fibroblasts responsible for building the collagen and elastin structure of the skin, skin lightening via tyrosinase inhibition, and skin penetration enhancing abilities (augmenting the availability of other active ingredients).
New research demonstrating profound anti-acne benefits
As if the benefits of phloretin weren’t impressive enough, researchers from the Biospectrum Life Science Institute of Korea have discovered that phloretin exhibits anti-acne properties. The findings were published in the August 2015 edition of the International Journal Of Cosmetic Science, and reveal that phloretin treats acne by effectively suppressing pathogenesis, both in vitro AND in vivo, through suppression of inflammatory response and the comedo formation of acne lesions.
Phloretin inhibits the growth of P. acnes, P. granulosum, and S. epidermidis and reduces sebum output
The study involved 30 healthy subjects with acne (specifically whiteheads) which used phloretin topically for a period of 4 weeks. Comedo counting, and the amount of sebum and porphyrin were measured before the treatment and following the 4 consecutive weeks of treatment with phloretin.
By the end of the trial, the results were remarkable! Phloretin inhibited the growth of P. acnes, P. granulosum, S. epidermidis and reduced inflammation through its potent anti-microbial activities. Whiteheads, blackheads, papules, sebum output level and amount of sebum and porphryn were significantly decreased when compared to before treatment. These findings suggest that phloretin is a potent and effective acne treatment.
Products with phloretin
By far the most popular product containing phloretin is the Skinceuticals Phloretin CF. This product has garnered immense praise and popularity, due to its formulation, which contains the synergistic combination of 2% phloretin, 10% vitamin C, and 0.5% ferulic acid. This specific combination has been shown to produce a powerful photoprotective effect on the skin.
Skinceuticals has another variation of this product, called the Phloretin CF Gel, which, just like the name suggests, has a more gel-like texture. Both products contain a high amount of denatured alcohol (which helps to enhance the penetration of ingredients), which makes them ideal only for oily, combination, and normal skin types.
Another fantastic product containing phloretin is the Cosmetic Skin Solutions Phloretin Serum Advanced Formula +, which features a similar formulation, but is a lot more affordable. This one is highly recommended for those not willing to spend upwards $160 on a 1oz bottle.
Phloretin is a powerhouse ingredient that treats hyperpigmentation (including PIH left behind by acne), fine lines, wrinkles, and acne. Its ability to not only reduce acne lesions, but also sebum secretion is incredibly exciting and has profound implications on the future of acne-fighting treatments.
• Evaluation of anti-acne properties of phloretin in vitro and in vivo